Flagyl 400 (Metronidazole 400 mg)

Overview:

When infections strike, especially those caused by bacteria and parasites, your doctor may prescribe Flagyl 400. This well-known antibiotic contains Metronidazole 400 mg, a medication trusted worldwide for decades to combat various infections. Whether it’s a dental abscess, gastrointestinal infection, or parasitic disease, Flagyl can be a game-changer — when used correctly.

What is Flagyl 400 (Metronidazole 400 mg)?

Flagyl 400 (Metronidazole 400 mg) is a powerful antibiotic-antiparasitic medication with a long-standing track record in treating various infections. When used responsibly under medical supervision, it can clear even stubborn infections efficiently.

Always remember that self-medicating with antibiotics is dangerous — misuse can lead to drug resistance, treatment failure, and side effects. If you suspect an infection, seek medical advice first.

Flagyl 400 is a prescription antibiotic containing Metronidazole, classified as a nitroimidazole antimicrobial. It works by entering the cells of microorganisms and disrupting their DNA synthesis, ultimately killing the bacteria or protozoa causing the infection.

Doctors often prescribe it for:

• Anaerobic bacterial infections
• Protozoal infections (e.g., giardiasis, trichomoniasis, amoebiasis)
• Certain dental and gum infections
• Post-surgical infection prevention

Metronidazole has a proven track record for treating anaerobic bacterial and protozoal infections effectively.

Medical Uses of Flagyl 400 (Metronidazole 400 mg)

1. Bacterial Infections

Metronidazole targets anaerobic bacteria — organisms that thrive without oxygen. These bacteria often cause:

• Intra-abdominal infections
• Skin and soft tissue infections
• Bone and joint infections
• Pelvic inflammatory disease

2. Protozoal Infections

Flagyl is widely used to treat parasitic conditions, such as:

• Giardiasis – a diarrheal illness caused by Giardia lamblia
• Amoebiasis – intestinal and liver infections caused by Entamoeba histolytica
• Trichomoniasis – a sexually transmitted infection caused by Trichomonas vaginalis

3. Dental and Oral Infections

Dentists may prescribe Flagyl for gum abscesses, periodontitis, and post-extraction infections, often in combination with other antibiotics.

4. Surgical Infection Prevention

In surgeries involving the gastrointestinal tract, Metronidazole may be given preoperatively to reduce infection risk.

How Does Metronidazole 400 mg Work?

Metronidazole enters microbial cells and interacts with their DNA, leading to strand breakage and inhibition of nucleic acid synthesis. This process kills the organism and clears the infection.

Unlike broad-spectrum antibiotics, it specifically targets anaerobic bacteria and certain protozoa, preserving most healthy gut bacteria.

How to take it?

• Take with food to reduce stomach upset.
• Complete the full course — stopping early may cause recurrence or resistance.
• Avoid alcohol during treatment and for at least 48 hours after — combining can cause severe nausea, vomiting, and flushing (disulfiram-like reaction).

Side Effects

While many tolerate Flagyl well, some may experience side effects:

• Nausea, vomiting, or stomach upset.
• Metallic taste in the mouth
• Headache
• Loss of appetite

Serious but rare side effects:

• Seizures
• Peripheral neuropathy (tingling/numbness in limbs)
• Severe allergic reaction (rash, itching, swelling)
• Dark urine (usually harmless, but should be reported)

Drug interactions:

• Alcohol
• Warfarin (increased bleeding risk)
• Lithium
• Certain seizure medications

Precautions & Warnings

Before starting Flagyl 400, inform your doctor if you have:

• Liver disease
• Kidney problems
• Neurological disorders
• Alcohol dependence
• Pregnancy or breastfeeding (safety should be evaluated by your doctor)

Storage Guidelines

• Store at room temperature (20–25°C)
• Keep away from light and moisture
• Keep out of reach of children

FAQs

1. Can I drink alcohol while taking Metronidazole 400?

No. Alcohol can cause severe reactions with Metronidazole, including nausea, vomiting, and flushing. Wait at least 48 hours after your last dose before drinking.

2. How quickly does Flagyl 400 start working?

Many patients notice improvement within 24–48 hours, but you should complete the full prescribed course even if you feel better.

3. Can Flagyl be taken on an empty stomach?

It’s best taken with food to reduce stomach irritation, though it can be taken without food if tolerated.

4. Is Flagyl 400 safe during pregnancy?

It’s generally avoided during the first trimester unless necessary. Only take under medical supervision.

5. How should I proceed if I miss a dose?

It is best to take it within a few minutes of remembering, unless it is nearly time for your next dose. Do not double the dosage.

6. Can Metronidazole cause yeast infections?

Yes. Altering normal bacterial balance can sometimes lead to fungal overgrowth, like vaginal yeast infections.

7. Is Flagyl an antibiotic or antiparasitic?

Both — it works against certain bacteria and protozoa, making it versatile in treating mixed infections.